ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones
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چکیده
منابع مشابه
ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones
E-cadherin plays a powerful tumor suppressor role. Germline E-cadherin mutations justify 30% of Hereditary Diffuse Gastric Cancer (HDGC) and missense mutations are found in 30% of these families. We found possible to restore in vitro mutant E-cadherin associated to HDGC syndrome by using Chemical Chaperones (CCs). Herein, our aim was to disclose the molecular mechanisms underlying the CCs effec...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0023188